Bistable regulation of adipocyte heterogeneity governs thermogenesis - Nature
health 2026/11/11 23:27:36

Bistable regulation of adipocyte heterogeneity governs thermogenesis - Nature

Source:Nature.com
Author:None

IL-1β from neutrophils and macrophages stabilizes nearby brown adipocytes in a low-UCP1 state; cold temperature reduces IL-1β via sympathetic nerves, leading to transition to a high-UCP1 state and increased thermogenesis, while higher temperatures h…