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Cell-free chromatin state tracing reveals disease origin and therapy responses - Nature
cf-EpiTracing enables automated profiling of histone modifications in cell-free DNA from human plasma, allowing identification of the cells of origin and disease diagnosis.
Genome modelling and design across all domains of life with Evo 2 - Nature
Evo 2 is an artificial intelligence-based biological foundation model trained on 9 trillion DNA base pairs spanning all domains of life that predicts functional properties from genomic sequences and provides a rich generative model for researchers in biology.
Mechanism of co-transcriptional cap snatching by influenza polymerase - Nature
Structural and biochemical studies of influenza virus RNA-dependent RNA polymerase (FluPol) in complex with transcribing host RNA polymerase II reveal the molecular mechanisms of RNA cap snatching by FluPol.
The molecular basis of force selectivity by PIEZO2 - Nature
PIEZO2 is intrinsically more rigid than PIEZO1, and disparate mechanical stimuli paradoxically evoke opposite conformational and gating responses in each channel.
Microbiota-mediated induction of beige adipocytes in response to dietary cues - Nature
In mice, a low-protein diet leads to a gut-microbiota-driven remodelling of adipose tissue towards brown fat, showing that gut microorganisms have a role in detecting and responding to a lack of protein.
Netflix, After Walking Away From Warner Bros. Deal, Will 'Move Forward' With '$2.8 Billion in Our Pocket That We Didn't Have a Few Weeks Ago,' CFO Says - Variety
Netflix CFO Spence Neumann, speaking Wednesday at the Morgan Stanley Technology, Media & Telecom Conference, reiterated the company’s position that it bailed out of the bidding for Warner Bros. because Paramount increased its offer price.