Postmitotic transcription and 3D regulation show locus-specific and differentiation-specific sensitivity to cohesin depletion - Nature
Source:Nature.com
Lee et al. deplete the cohesin component RAD21 in mouse embryonic stem cells. Most but not all chromatin loops fail to reform after mitosis, and transcriptional changes were minor, except during differentiation, where cohesin seems to have a more important ro…
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